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• tau铔嬬櫧鍙婂叾淇グ

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涓嶅悓绫诲瀷tau铔嬬櫧鐨勪慨楗板浣?/span>鐩镐簰褰卞搷銆?strong>寮傚父淇グ鎬庢牱褰卞搷AD绛変粛鏈夊緟杩涗竴姝ョ爺绌躲€?/span>

• tau涓嶢D涓殑绁炵粡鍏冨強绁炵粡鐜矾娲绘€у紓甯?/span>

杩囪〃杈総au铔嬬櫧鍙互鎶戝埗鐨眰鍏村鎬х缁忓厓鐨勬椿鎬э紝涓旇繖涓€浣滅敤骞朵笉渚濊禆浜嶯FTs鐨勫瓨鍦紝鍙憾鎬х殑tau铔嬬櫧鍦ㄦ鍙戞尌涓昏浣滅敤銆?span style=”color: #595959; –tt-darkmode-color: #595959;”>浣嗚繃琛ㄨ揪tau铔嬬櫧鏄惁鍙姂鍒跺叾浠栬剳鍖哄娴烽┈涓缁忓厓鐨勬椿鎬э紝鐩墠杩樹笉娓呮銆?/span>

鍦ˋPP/PS1灏忛紶涓繃琛ㄨ揪tau铔嬬櫧鍚庯紝鐨眰涓紓甯告椿璺冪殑绁炵粡鍏?/span>鏄捐憲鍑忓皯锛宼au铔嬬櫧鍙互鎶垫秷A尾杩囧瀵艰嚧鐨勭毊灞傚叴濂嬫€х缁忓厓娲绘€у崌楂樸€傜劧鑰岋紝tau铔嬬櫧杩囪〃杈炬槸鍚﹀彲浠ユ姷娑圓尾杩囧瀵艰嚧鐨勫叾浠栬剳鍖哄娴烽┈涓叴濂嬫€х缁忓厓娲绘€у崌楂橈紝鐩墠灏氫笉娓呮銆?/span>

tau铔嬬櫧浠嬪浜?/span>A尾杩囧寮曡捣鐨勭缁忕幆璺?缃戠粶娲诲姩寮傚父澧炲己銆?strong>A尾-tau-Fyn杩欎竴閫氳矾鍙兘鏄疉D灏忛紶涓缁忕幆璺椿鍔ㄥ紓甯稿寮哄苟鏈€缁堝鑷磋鐭ラ殰纰嶇殑閲嶈鍘熷洜銆?/span>

鍦?/span>绐佽Е浼犻€?/span>灞傞潰锛宼au缂哄け鍙兘閫氳繃澧炲己鎶戝埗鎬х缁忓厓鐨勬椿鎬?/span>鑰岄樆姝尾寮曡捣鐨勫叴濂嬫€х缁忓厓杩囧害娲昏穬銆?/span>

鍦?/span>缁嗚優灞傞潰锛宼au缂哄け鏄惁鐪熺殑鑳藉澧炲己鎶戝埗鎬х缁忓厓鐨勬椿鎬э紵鏄惁鍙互闃绘A尾杩囧寮曡捣鐨勭毊灞傛垨娴烽┈鍏村鎬х缁忓厓杩囧害娲昏穬锛熺洰鍓嶈繕涓嶆竻妤氥€?/span>

鏃犺鏄惁瀛樺湪A尾锛?/span>杩囪〃杈総au铔嬬櫧閮藉彲浠ユ姂鍒跺叴濂嬫€х缁忓厓鐨勬椿鎬с€傝€?strong>tau铔嬬櫧缂哄け鍒欐姂鍒朵簡hAPP灏忛紶鐨眰鍙婃捣椹唴鐨勭櫕鐥牱鏀剧數鍙婂皬榧犵殑鐧棲鍙戜綔锛屾彁绀簍au缂哄け鍙樆姝APP/A尾寮曡捣鐨勭缁忕綉缁滆繃搴︽椿璺冦€?/span>

鍦ˋD鎮ｈ€呰剳涓璽au铔嬬櫧绌剁珶鏄€庢牱褰卞搷绁炵粡鍏冩椿鎬ф垨绁炵粡鐜矾/缃戠粶鐨勬椿鍔ㄧ殑锛熷湪AD鐥呯▼鐨勪笉鍚岄樁娈碉紝tau铔嬬櫧瀵圭缁忓厓鍙婄缁忕幆璺?缃戠粶娲诲姩鐨勫奖鍝嶆槸鍚﹀瓨鍦ㄥ樊寮傦紵涓轰簡鍑忚交AD鎮ｈ€呰剳涓缁忓厓娲绘€ф垨绁炵粡鐜矾娲诲姩寮傚父锛屽簲璇ュ噺灏戣繕鏄鍔爐au铔嬬櫧鐨勮〃杈撅紵鍧囬渶瑕?/span>杩涗竴姝ョ殑瀹為獙鎺㈢┒銆?/span>

ApoE涓嶢D涓殑绁炵粡鍏冨強

绁炵粡鐜矾娲绘€у紓甯?/span>

ApoE鏄竴绉?/span>杞借剛铔嬬櫧锛屼富瑕佸弬涓庤剛绫昏繍杈擄紝鍦ㄨ儐鍥洪唶浠ｈ阿鍙婂績琛€绠＄柧鐥呬腑鍏锋湁閲嶈浣滅敤锛屼汉鐨凙poE鍖呮嫭ApoE2銆?em>ApoE3鍜?em>ApoE4杩?绉嶇被鍨嬨€?/span>

姝ｅ父鎯呭喌涓嬶紝鑴戜腑鐨凙poE涓昏鍦?/span>鏄熷舰鑳惰川缁嗚優涓〃杈撅紝浣嗗湪搴斿琛拌€佸拰搴旀縺鐨勬儏鍐典笅锛?strong>绁炵粡鍏?/span>涔熷彲浠ョ敓鎴怉poE锛岀缁忓厓鍐呯殑ApoE鏇村鏄撹闄嶈В鑰屼骇鐢?strong>鍏锋湁姣掓€х殑鐗囨銆?/span>

鎼哄甫涓€涓嫹璐?/span>ApoE4鐨勪釜浣撴偅AD鐨勫嚑鐜囨槸姝ｅ父浜虹殑3~4鍊?/span>锛岃€?涓嫹璐?em>ApoE4鎼哄甫鑰呮偅AD鐨勫嚑鐜囨槸姝ｅ父浜虹殑12鍊?/span>銆侫poE4涔熷洜姝ゆ垚涓鸿繜鍙戝瀷鎴栨暎鍙戝瀷AD鏈€涓昏鐨勯仐浼犲鍗遍櫓鍥犲瓙銆?/span>

ApoE4鍙兘閫氳繃淇冭繘娣€绮夋牱鏂戝潡鐨勫舰鎴?/span>浠ュ強鎶戝埗A尾鐨勬竻闄?/span>鑰岄€犳垚A尾鐨勫紓甯哥Н绱紝浠庤€屽弬涓嶢尾渚濊禆鐨勪竴绯诲垪姣掓€ф晥搴斻€?em>ApoE4涔熷彲浠ラ€氳繃闈濧尾渚濊禆鐨勯€斿緞鑰屽奖鍝岮D杩涚▼銆?/span>

绁炵粡鍏冧腑鐨?/span>ApoE4鍦ㄥ簲瀵硅“鑰佹垨搴旀縺杩囩▼涓細琚檷瑙ｈ€屼骇鐢熸瘨鎬х墖娈碉紝杩欎簺鐗囨鍙?/span>淇冭繘tau铔嬬櫧鐨勭７閰稿寲锛屼篃浼氫笌绾跨矑浣撶浉浜掍綔鐢ㄨ€岄€犳垚绾跨矑浣撳姛鑳芥崯浼?/span>锛岃繘鑰屽鑷寸缁忓厓姝讳骸銆?/span>

ApoE4鐨勮〃杈惧彲鑳藉紩璧?/span>绁炵粡缃戠粶娲诲姩寮傚父锛?em>ApoE4鍙兘閫氳繃鍑忓皯鎶戝埗鎬х缁忓厓鐨勬暟閲?/span>鑰屽鑷存捣椹唴绁炵粡鐜矾寮傚父杩涜€屽紩璧疯鐭ュ姛鑳芥崯浼ゃ€?/span>

GABA绁炵粡鍏冩崯浼?/span>鏄?/span>ApoE4寮曡捣璁ょ煡闅滅鐨勯噸瑕佸洜绱狅紝绁炵粡鍏冧腑琛ㄨ揪鐨?/span>ApoE4鏄鑷存捣椹珿ABA绁炵粡鍏冩浜＄殑涓昏鍘熷洜锛岃€屼笖tau浠嬪浜?/span>ApoE4寮曡捣鐨?/span>鐥呯悊鎬ф崯浼?/span>銆?/span>

鍦ㄦ惡甯?/span>ApoE4鐨凙D鎮ｈ€呬腑锛?/span>ApoE4鍙互閫氳繃淇冭繘A尾绱Н鍙?strong>tau铔嬬櫧纾烽吀鍖?/span>鑰屼績杩汚D鐨勮繘灞曪紝A尾绱Н浠ュ強琛拌€佺瓑鍥犵礌鍙互璇卞ApoE4鍦ㄧ缁忓厓涓〃杈惧苟浜х敓绁炵粡姣掓€х墖娈碉紝杩欎簺鐗囨鍦╰au铔嬬櫧浠嬪涓嬪紩璧锋捣椹腑鎶戝埗鎬х缁忓厓鏁伴噺鍑忓皯鎴栧姛鑳芥崯浼わ紝閫犳垚绁炵粡鐜矾娲诲姩寮傚父骞舵渶缁堝鑷磋鐭ュ姛鑳介殰纰嶃€?/span>

鐐庢€у弽搴斾笌AD涓缁忓厓娲绘€у紓甯?/span>

灏忚兌璐ㄧ粏鑳炵壒寮傛€ц〃杈?/span>鐨勫涓熀鍥犲彉寮備笌AD瀵嗗垏鐩稿叧锛屽畠浠彲鑳藉弬涓庝簡A尾鍙妕au铔嬬櫧鐨?/span>娌夌Н銆佽浆杩愬拰娓呴櫎绛夈€?/span>

姝ゅ锛孉尾鍙妕au鐨?/span>绱Н浼氬鑷村皬鑳惰川缁嗚優鍜屾槦褰㈣兌璐ㄧ粏鑳?strong>褰㈡€佸強鍔熻兘寮傚父锛岃繖浜涘紓甯哥殑鑳惰川缁嗚優鍙兘鍦ˋD鐨勭缁忕幆璺強绁炵粡鍏冩椿鎬у紓甯镐腑鍙戞尌浣滅敤銆?/span>

灏忚兌璐ㄧ粏鑳為€氳繃绐佽Е淇壀鑰屽奖鍝嶇缁忓彂鑲层€傚湪鎴愬勾鑴戜腑锛屽皬鑳惰川缁嗚優閫氳繃涓庣缁忓厓鍜屾槦褰㈣兌璐ㄧ粏鑳炵浉浜掍綔鐢紝瀵?strong>绁炵粡绯荤粺绋虫€?/span>鐨勭淮鎸佽嚦鍏抽噸瑕併€?/span>

娲诲寲鐨勫皬鑳惰川缁嗚優浠嬪鐨?/span>ATP-AMPADO浠ｈ阿閫氳矾寮傚父鍙兘鍙備笌浜咥D灏忛紶娴烽┈鍙婄毊灞傜缁忓厓杩囧害娲昏穬鐨勮皟鎺э紝濡傛灉鑳藉姝よ繘琛岄獙璇侊紝鏈夊彲鑳戒负AD涓缁忓厓鍙婄缁忕幆璺椿鍔ㄥ紓甯哥殑璋冩帶鎻愪緵鏂扮殑閫斿緞銆?/span>

鏄熷舰鑳惰川缁嗚優鍙備笌绐佽Е缁撴瀯鍜屽姛鑳界殑缁存寔锛屽苟鍦ㄧ缁忕幆璺?缃戠粶娲诲姩鐨勮皟鎺т腑鍏锋湁閲嶈浣滅敤銆?/span>

鍦ˋD涓紝A尾鍙妕au鐨勭疮绉垨鍏朵粬鍥犵礌鍙鑷存槦褰㈣兌璐ㄧ粏鑳?/span>褰㈡€佸拰鍔熻兘鍙戠敓鍙樺紓锛屼粠鑰屽绁炵粡鍏冩椿鎬с€佺獊瑙︿紶閫掑強绐佽Е鍙鎬с€佺缁忕幆璺?缃戠粶娲诲姩浜х敓褰卞搷锛屾渶缁堝紩璧疯鐭ュ姛鑳介殰纰嶃€?/span>

AD涓殑鐐庢€у弽搴?/span>鍙鑷村皬鑳惰川缁嗚優鍜屾槦褰㈣兌璐ㄧ粏鑳炵粨鏋勫拰鍔熻兘寮傚父锛岃繖浜涘紓甯哥殑鑳惰川缁嗚優鍙兘鍙備笌浜嗙缁忓厓娲绘€у紓甯稿強绁炵粡鐜矾娲诲姩闅滅鐨勮皟鎺с€?/span>

瑙ｆ瀽鍏朵腑鐨勬満鍒舵湁鍙兘涓烘彮绀篈D鐨勭梾鐞嗘満鍒跺苟瀵瑰叾杩涜闃叉不鎻愪緵鏂扮殑閫斿緞銆?/span>

鎴愪綋绁炵粡鍙戠敓涓嶢D涓殑绁炵粡鍏?/span>

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