an姘ㄥ熀閰?/strong>
a leap in the dark 鍐掗櫓琛屼负锛岃交涓惧鍔?br/>look before your leap 涓夋€濊€屽悗琛?br/>a shot in the arm 鍒烘縺鍥犵礌锛屽己蹇冨墏 锛?楹婚唹鐨笅娉ㄥ皠锛涘叴濂嬪墏
abuse of dominant market 婊ョ敤甯傚満鏀厤鍦颁綅
Academy Awards 濂ユ柉鍗￠噾鍍忓
accessible elevator 鏃犻殰纰嶇數姊?br/>accident rate 浜嬫晠鍙戠敓鐜囷紝鎰忓浼ゅ鐜?br/>accomodative monetary policy 铻嶉€氭€ц揣甯佹斂绛?br/>account balance 璐﹀彿浣欓锛岃处鍙风粨浣?br/>acculturation 鏂囧寲閫傚簲锛屾枃鍖栦箣浼犳巿锛涙枃鍖栫Щ鍏?br/>accumulated fund 绱璧勯噾
ad-hoc 鐐瑰鐐规ā寮忥紝鐗瑰畾锛屼笓闂紝 涓存椂
advance payment 瀹氶噾锛岄浠樻
advanced economy 鍏堣繘缁忔祹浣擄紝鍙戣揪缁忔祹
advantages of a late comer 鍚庢柟浼樺娍
advertising slot 骞垮憡鏃舵
aerial refueling 绌轰腑鍔犳补
aerobic exercise 鏈夋哀杩愬姩
after-sales service 鍞悗鏈嶅姟
aggregate demand 鎬婚渶姹?br/>air disaster 绌洪毦锛岄鏈哄け浜?br/>air freight 绌鸿繍
air raid/air strike 绌鸿
Airbnb 鐖卞郊杩?锛堢編鍥界煭绉熷钩鍙帮級
Airbus 绌轰腑瀹㈣溅鍏徃锛堢┖瀹級
aircraft carrier 鑸┖姣嶈埌
algorithm 绠楁硶
All soul’s Day 涓囩伒鑺?br/>all-in-one ticket 涓€绁ㄩ€?br/>all-round contract system 澶у寘骞?br/>alternating current circuit 浜ゆ祦鐢佃矾
altitude sickeness 楂樺師鍙嶅簲
American exceptionalism 缇庡浗渚嬪璁?br/>amino acid 姘ㄥ熀閰?br/>an independent voter 鏃犲厷娲鹃€夋皯
anarchist 鏃犳斂搴滀富涔夎€?br/>angel investment 澶╀娇鎶曡祫
Angkor Wat 鍚村摜绐?br/>animated movie 鍔ㄧ敾鐢靛奖
Annual Garmmy Wards 骞村害鏍艰幈缇庡
Ant Finacial 铓傝殎閲戞湇
anti-ballistic missle 鍙嶅脊閬撳寮?br/>anti-counterfeit label 闃蹭吉鏍囪瘑
anti-depressant 鎶楁姂鍒跺墏锛屾姉鎶戝埗鑽?br/>antifa(antifascist action) 鍙嶆硶瑗挎柉杩愬姩
anti-fascist 鍙嶆硶瑗挎柉涓讳箟鑰?br/>anti-monopoly legislation 鍙嶅瀯鏂珛娉?br/>antioxidant 鎶楁哀鍖栧墏
anti-riot police 闃茬垎璀﹀療
anti-Semitism 鍙嶇姽澶富涔?br/>appeals court 涓婅堪娉曞涵
applet 搴旂敤灏忕▼搴?br/>appoint and empower 濮旀墭鍜屾巿鏉?br/>appraiser 閴村畾甯堬紝璇勪及甯?br/>arable land 鍙€曞湴
arbitration clause 浠茶鏉℃
Arbor Day 锛堢編鍥斤級妞嶆爲鑺?br/>Armistice Day 浼戞垬绾康鏃?br/>armored vehicle 瑁呯敳杞?br/>artificial neural network 浜哄伐绁炵粡缃戠粶
A-share market A鑲″競鍦?br/>assmebly plant 瑁呴厤宸ュ巶
asset portfolio 璧勪骇缁勫悎
asset prie bubble 璧勪骇浠锋牸娉℃搏
asset-backed securitization 璧勪骇鏀拺璇佸埜鍖?br/>assume office 灏辫亴锛屽埌浠?br/>asteroid collision 灏忚鏄熺鎾?br/>astrology 鍗犳槦鏈紝鍗犳槦璇?
astrophysics 澶╀綋鐗╃悊瀛?br/>at the end of one’s rope 鎵嶆櫤鏋锛屽北绌锋按灏?br/>atheism 鏃犵璁?br/>audience rating 鏀惰鐜?br/>authoritarianism 鐙涓讳箟
autocracy 鐙鏀挎不锛屼笓娌绘斂娌?br/>autonomous vehicle 鑷姩椹鹃┒姹借溅
avant -garde 鍏堥攱娲?br/>average life expectancy 骞冲潎棰勬湡瀵垮懡
avian influenza/bird flu 绂芥祦鎰?/div>
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婢庢箖鏂伴椈棣栧腑璁拌€?璐烘ⅷ钀?/p>
鈥滈殢鐫€鏃朵唬鐨勪笉鍚岋紝鏈変簺闂鍘熸潵涓嶉噸瑕佺殑锛屽彉寰楄秺鏉ヨ秺閲嶈浜嗐€傗€濆箍涓滅渷鑲虹檶鐮旂┒鎵€鍚嶈獕鎵€闀垮惔涓€榫欐暀鎺堟墍璋堢殑鏄偤鐧屾不鐤楃殑鍚堢悊鐢ㄨ嵂璇濋銆?/p>
杩戞棩锛屽惔涓€榫欏湪鎺ュ彈婢庢箖鏂伴椈锛坵ww.thepaper.cn锛夌瓑濯掍綋閲囪鏃惰〃绀猴紝浠LK闃虫€ф偅鑰呬负渚嬶紝鈥滃湪鍗佸嚑骞村墠锛屾垜浠彧鏈変竴涓嵂锛屽厠鍞戞浛灏硷紝閭ｄ釜鏃跺€欐垜浠渶瑕佽皥鍚堢悊鐢ㄨ嵂鍚楋紵褰撶劧涓嶉渶瑕侊紝鍥犱负娌″緱閫夋嫨銆備絾鏄埌浜嗕粖澶╋紝褰撴垜浠湁闈炲父澶氳嵂鐨勬椂鍊欏氨蹇呴』瑕佹潵璋堝悎鐞嗙敤鑽殑闂浜嗐€傗€?/p>
ALK鍗抽棿鍙樻€ф穻宸寸槫婵€閰?Anaplastic Lymphoma Kinase锛孉LK)锛屾槸涓€绉嶅彈浣撻叒姘ㄩ吀婵€閰讹紝涓庤娑层€侀棿璐ㄥ拰瀹炰綋涓夊ぇ绫诲瀷鑲跨槫鐩稿叧銆傛鍓嶇殑鐮旂┒鏄剧ず锛岀害3%-7锛呯殑闈炲皬缁嗚優鑲虹檶(NSCLC)鎮ｈ€呬綋鍐呰偪鐦ゆ煋鑹蹭綋EML4鍩哄洜澶栨樉瀛愪笌ALK鍩哄洜澶栨樉瀛愯瀺鍚堬紝褰㈡垚EML4-ALK铻嶅悎閰皑閰告縺閰讹紝EML4-ALK铻嶅悎鍙樺紓浣撳叿鏈夐珮搴︾殑鑷寸檶鎬э紝涓擜LK鍦ㄥ绉嶈偪鐦ょ粏鑳炰腑楂樿〃杈俱€?/p>
姝ｅ洜濡傛锛孉LK鏄竴涓瀬鍏峰惛寮曞姏鐨勮偤鐧屾不鐤楅澏鐐癸紝涔熻绉颁负鑲虹檶鐨勨€滈捇鐭斥€濋澏鐐广€傗€滃洜涓鸿繖涓€橀捇鐭斥€欑獊鍙樻病鏈夎嵂鐨勬椂鍊欐瘮鍏朵粬鐨勯兘鎭舵€э紝浣嗘槸鏈変簡鑽箣鍚庢瘮鍏朵粬鐨勭敓瀛樻椂闂撮兘瑕侀暱銆傗€濆惔涓€榫欒В閲娿€?
ALK闃虫€ц偤鐧屾偅鑰呯殑鈥滄晳鏄熲€濅簬2011骞撮棶涓栥€傚郊鏃讹紝杈夌憺鍏徃锛圥fizer锛夊紑鍙戠殑绗竴浠LK鎶戝埗鍓傚厠鍞戞浛灏艰幏缇庡浗椋熷搧鍜岃嵂鍝佺洃鐫ｇ鐞嗗眬锛團DA锛夋壒鍑嗕笂甯傘€?骞翠箣鍚庯紝涓ゆ鈥滃崌绾р€濆悗鐨勭涓変唬ALK鎶戝埗鍓備篃杩涘叆浜嗗競鍦恒€傚氨鍦ㄦ鍓嶇殑4鏈堝簳锛岃緣鐟炲紑鍙戠殑鍏ㄧ悆棣栦釜绗笁浠LK鎶戝埗鍓傚崥鐟炵撼庐锛圠orbrena庐锛岄€氱敤鍚嶏細娲涙媺鏇垮凹鐗?Lorlatinib Tablets锛夎幏涓浗鍥藉鑽搧鐩戠潱绠＄悊灞€鎵瑰噯锛屽崟鑽€傜敤浜庨棿鍙樻€ф穻宸寸槫婵€閰讹紙ALK锛夐槼鎬х殑灞€閮ㄦ櫄鏈熸垨杞Щ鎬ч潪灏忕粏鑳炶偤鐧岋紙NSCLC锛夋偅鑰呯殑娌荤枟銆?/p>
鈥滀粠绉戝鎬ц搴︽潵璁诧紝ALK鎶戝埗鍓傚崟鑽氨宸茬粡鍙互鏄剧ず闈炲父濂界殑鏁堟灉銆傛墍浠ヤ粠娌荤枟绛栫暐鎴栬€呮墍鏈夌殑鎸囧崡銆佹墍鏈夌殑璇佹嵁涔熷ソ锛岄兘浼氬己璋冨崟鑽疉LK鎶戝埗鍓傛不鐤桝LK闃虫€ф偅鑰呫€傗€?涓婃捣浜ら€氬ぇ瀛﹂檮灞炶兏绉戝尰闄€佷笂娴峰競鑲洪儴鑲跨槫涓村簥鍖诲涓績涓讳换闄嗚垳鏁欐巿鍦ㄦ帴鍙楁編婀冩柊闂伙紙www.thepaper.cn锛夎鑰呮椂濡傛槸琛ㄧず銆?/p>
绗笁浠LK鎶戝埗鍓傦細鏃犺繘灞曠敓瀛樻湡宸茬獊鐮翠笁骞?/strong>
鍦ㄤ笘鐣岃寖鍥村唴锛岃偤鐧屽眳鎭舵€ц偪鐦ゆ浜″師鍥犵殑棣栦綅銆傝偤鐧屽垎涓哄皬缁嗚優鑲虹檶锛堢害鍗犳墍鏈夎偤鐧岀殑15%锛夊拰闈炲皬缁嗚優鑲虹檶銆傝€屽湪涓浗锛岃偤鐧屼篃楂樺眳鍙戠梾鐜囧拰姝讳骸鐜囬浣?锛屽叾涓瑼LK闃虫€ф櫄鏈熼潪灏忕粏鑳炶偤鐧屾偅鑰呭钩鍧囧勾榫勫湪52宀併€?/p>
姝ゅ鏈夋暟鎹樉绀猴細20-40%鐨凙LK闃虫€ф櫄鏈熼潪灏忕粏鑳炶偤鐧屾偅鑰呭湪鍒濊瘖鏃跺氨宸插彂鐢熻剳杞Щ锛屼笖鍙戠敓鐜囬殢鏃堕棿寤堕暱鑰屽崌楂橈紝鍗充娇缁忚繃ALK鎶戝埗鍓傛不鐤楋紝45-70%鐨勬偅鑰呬篃浼氬嚭鐜拌剳閮ㄨ繘灞?锛屽鎮ｈ€呯敓瀛樺甫鏉ヤ弗宄绘寫鎴樸€?/p>
鍚翠竴榫欒涓猴紝缁忚繃杩戜簩鍗佸勾鐨勬帰绱紝鑲虹檶棰嗗煙鍦ㄤ袱涓瀛﹁蹇电殑寮曞涓嬩骇鐢熶簡闈炲父澶х殑绐佺牬銆?/p>
绗竴涓氨鏄惊璇佸尰瀛︼紝鈥滃惊璇佸尰瀛︾殑鏍稿績鐗圭偣灏辨槸浠ヤ复搴婅瘯楠屼负涓績锛屼互涓村簥璇曢獙鐨勬暟鎹潵璇磋瘽銆傛墍浠ワ紝鎴戜滑鐜板湪璋堟墍鏈夌殑娌荤枟绂讳笉寮€鏁版嵁锛岀涓嶅紑涓村簥璇曢獙銆傗€濈浜屽垯鏄簿鍑嗗尰瀛︼紝鈥滅簿鍑嗗尰瀛﹁窡寰瘉鍖诲涓嶆槸鐭涚浘鐨勶紝鑰屾槸鐩歌緟鐩告垚鐨勩€傛垜浠粖澶╃殑绮惧噯鍖诲鏍稿績鏄互鍒嗗瓙鐢熺墿瀛︾殑鏀瑰彉鏉ュ鑲虹檶杩涜浠旂粏鐨勫垎鍨嬶紝鐒跺悗鍦ㄥ垎鍨嬬殑鍩虹涓婃寚瀵兼垜浠殑娌荤枟锛岃繖鍙仛绮惧噯鍖诲銆傗€?/p>
涓婅堪鎻愬埌鐨凙LK鍒嗗瀷锛屽氨鏄簿鍑嗗尰瀛︾殑涓€閮ㄥ垎銆侫LK鏄竴绉嶅彈浣撻叒姘ㄩ吀婵€閰讹紝灞炰簬鑳板矝绱犲彈浣撹秴瀹舵棌锛屼笌鐧界粏鑳為叒姘ㄩ吀婵€閰跺叿鏈夐珮搴﹀悓婧愭€с€傝鍩哄洜浣嶄簬浜虹被鏌撹壊浣?p23娈碉紝缂栫爜1620涓皑鍩洪吀鐨勫鑲斤紝缁忚繃缈昏瘧鍚庝慨楗帮紝鐢熸垚200- 220鍗冮亾灏旈】锛坘Da锛夌殑鎴愮啛ALK铔嬬櫧銆侫LK鍩哄洜鍙縺娲诲涓粏鑳炲唴淇″彿閫氳矾锛屼粠鑰屽弬涓庤皟鑺傜粏鑳炵敓闀裤€佽浆鍖栦互鍙婃姉缁嗚優鍑嬩骸鐨勮繃绋嬨€?/p>
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杈夌憺鍏徃鐨勫厠鎸浛灏兼嫈寰楀ご绛广€傚惔涓€榫欐彁鍒帮紝鈥滃厠鍞戞浛灏煎綋鏃剁粰澶у甯︽潵闈炲父澶х殑甯屾湜锛屽洜涓虹敤鍏嬪攽鏇垮凹鏉ユ不鐤桝LK铻嶅悎锛屾晥鏋滃ぇ澶ц秴杩囦簡杩囧幓鍞竴鐨勬不鐤楁柟妗堬紝涔熷氨鏄寲鐤楋紝鑰屾瘨鍓綔鐢ㄦ瘮璧峰寲鐤楀ぇ澶у噺杞汇€傗€?/p>
鐒惰€岋紝浣滀负绗竴浠LK鎶戝埗鍓傦紝鍏嬫尗鏇垮凹涓綅鏃犵柧鐥呰繘灞曠敓瀛樻椂闂翠粎绾?1涓湀锛屸€滆繖涓椂鍊欏氨浜х敓涓€涓棶棰橈紝杩欏氨鏄垜浠О涓哄尰瀛︿笂鏈婊¤冻鐨勶紙娌荤枟闇€姹傦級銆備负浠€涔堝彧鏈?1涓湀锛熻兘涓嶈兘鏇撮暱锛熷鏋滆兘鏇撮暱鐨勮瘽锛岄偅杩欏氨鏄复搴婇渶瑕佺殑銆傗€?/p>
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